human BACE2 shRNA silencing AAV

Name
AAV-h-BACE2-shRNA

Cat No
shAAV-201931

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human BACE2.

shAAV-201931

AAV-h-BACE2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BACE2 (beta-site APP-cleaving enzyme 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP

Description (Vector)

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.

Gene ID

25825

Gene Name (Vector)

beta-site APP-cleaving enzyme 2

Gene Symbol

BACE2

HGNC ID

HGNC:934

ORF Size (aa)

1557

ORF Size (bp)

1557 bp

RefSeq ID

NM_012105

RefSeq Synonyms

NM_138992, NM_138991, NM_012105, BC014453,

Species

human

UniGene ID

Hs.529408

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.