human ATXN3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ATXN3.
shAAV-201815
AAV-h-ATXN3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ATXN3 (ataxin 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AT3; ATX3; JOS; MJD; MJD1; SCA3;
Description (Vector)
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
4287
Gene Name (Vector)
ataxin 3
Gene Symbol
ATXN3
HGNC ID
HGNC:7106
ORF Size (aa)
1113
ORF Size (bp)
1113 bp
RefSeq ID
NM_004993
RefSeq Synonyms
NM_030660, NM_004993, NM_001164782, NM_001164781, NM_001164780, NM_001164779, NM_001164778, NM_001164777, NM_001164776, NM_001164774, NM_001127697, NM_001127696, BC095402, BC033711,
Species
human
UniGene ID
Hs.532632
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.