human ATP2B3 shRNA silencing AAV

Name
AAV-h-ATP2B3-shRNA

Cat No
shAAV-201694

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ATP2B3.

shAAV-201694

AAV-h-ATP2B3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CFAP39; CLA2; OPCA; PMCA3; PMCA3a; SCAX1

Description (Vector)

ATP2B3 belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

492

Gene Name (Vector)

ATPase plasma membrane Ca2+ transporting 3

Gene Symbol

ATP2B3

HGNC ID

HGNC:816

ORF Size (aa)

2625

ORF Size (bp)

2625 bp

RefSeq ID

NM_001001344

RefSeq Synonyms

NM_021949, NM_001001344, BC130009,

Species

human

UniGene ID

Hs.658008

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.