human ATP1B3 shRNA silencing AAV

Name
AAV-h-ATP1B3-shRNA

Cat No
shAAV-201686

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ATP1B3.

shAAV-201686

AAV-h-ATP1B3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ATP1B3 (ATPase Na+/K+ transporting subunit beta 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ATPB-3; CD298

Description (Vector)

ATP1B3 belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2.

Gene ID

483

Gene Name (Vector)

ATPase Na+/K+ transporting subunit beta 3

Gene Symbol

ATP1B3

HGNC ID

HGNC:806

ORF Size (aa)

840

ORF Size (bp)

840 bp

RefSeq ID

NM_001679

RefSeq Synonyms

NM_001679, BC011835,

Species

human

UniGene ID

Hs.477789

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.