human ATP1A3 shRNA silencing AAV

Name
AAV-h-ATP1A3-shRNA

Cat No
shAAV-201681

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ATP1A3.

shAAV-201681

AAV-h-ATP1A3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AHC2; ATP1A1; CAPOS; DYT12; RDP

Description (Vector)

ATP1A3 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

478

Gene Name (Vector)

ATPase Na+/K+ transporting subunit alpha 3

Gene Symbol

ATP1A3

HGNC ID

HGNC:801

ORF Size (aa)

3042

ORF Size (bp)

3042 bp

RefSeq ID

NM_152296

RefSeq Synonyms

NM_152296, NM_001256214, NM_001256213, BC015566, BC009394, BC009282,

Species

human

UniGene ID

Hs.515427

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.