human ASGR2 shRNA silencing AAV

Name
AAV-h-ASGR2-shRNA

Cat No
shAAV-201554

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ASGR2.

shAAV-201554

AAV-h-ASGR2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ASGR2 (asialoglycoprotein receptor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ASGP-R2; ASGPR2; CLEC4H2; HBXBP; HL-2

Description (Vector)

ASGR2 encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

433

Gene Name (Vector)

asialoglycoprotein receptor 2

Gene Symbol

ASGR2

HGNC ID

HGNC:743

ORF Size (aa)

864

ORF Size (bp)

864 bp

RefSeq ID

NM_001181

RefSeq Synonyms

NM_080914, NM_080913, NM_080912, NM_001201352, NM_001181, BC017251,

Species

human

UniGene ID

Hs.654440

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.