human ARTN shRNA silencing AAV

Name
AAV-h-ARTN-shRNA

Cat No
shAAV-201503

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ARTN.

shAAV-201503

AAV-h-ARTN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARTN (artemin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ART; ENOVIN; EVN; NBN

Description (Vector)

ARTN is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

9048

Gene Name (Vector)

artemin

Gene Symbol

ARTN

HGNC ID

HGNC:727

ORF Size (aa)

687

ORF Size (bp)

687 bp

RefSeq ID

NM_001136215

RefSeq Synonyms

NM_057091, NM_057090, NM_001136215, BC062375,

Species

human

UniGene ID

Hs.632404

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.