human ARSA shRNA silencing AAV

Name
AAV-h-ARSA-shRNA

Cat No
shAAV-201484

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ARSA.

shAAV-201484

AAV-h-ARSA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARSA (arylsulfatase A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MLD

Description (Vector)

ARSA hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.

Gene ID

410

Gene Name (Vector)

arylsulfatase A

Gene Symbol

ARSA

HGNC ID

HGNC:713

ORF Size (aa)

1524

ORF Size (bp)

1524 bp

RefSeq ID

NM_000487

RefSeq Synonyms

NM_001085428, NM_001085427, NM_001085426, NM_001085425, NM_000487, BC014210,

Species

human

UniGene ID

Hs.88251

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.