human ARID4A shRNA silencing AAV

Name 
AAV-h-ARID4A-shRNA
Cat No 
shAAV-201382
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ARID4A.

shAAV-201382
AAV-h-ARID4A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARID4A (AT-rich interaction domain 4A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ARID domain-containing protein 4A; AT rich interactive domain 4A (RBP1-like); AT-rich interactive domain-containing protein 4A; RBBP1; RBBP-1; RBP1; RBP-1; retinoblastoma-binding protein 1
Description (eCommerce)
ARID4A (AT-rich interactive domain-containing protein 4A) is a retinoblastoma binding protein and member of the AT-rich interaction domain (ARID) family of proteins. In addition to the ARID DNA binding domain, ARID4A also contains a chromo domain and a TUDOR domain, indicating a function in chromatin organization and protein-protein interactions with methylated protein substrates. ARID4A is implicated to be involved in chromatin remodeling and epigenetic modifications and to play a role in the pathogenesis of cancer.
Description (Vector)
ARID4A is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.
Gene ID
5926
Gene Name (eCommerce)
AT-rich interaction domain 4A
Gene Name (Vector)
AT-rich interaction domain 4A
Gene Symbol
ARID4A
HGNC ID
HGNC:9885
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3567
ORF Size (bp)
3567 bp
Protein Name (eCommerce)
AT-rich interactive domain-containing protein 4A
RefSeq ID
NM_002892
RefSeq Synonyms
NM_023001, NM_023000, NM_002892, BC172363,
Research Areas
Chromatin Remodeling,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
ARID4A (AT-rich interactive domain-containing protein 4A) is a retinoblastoma binding protein and member of the AT-rich interaction domain (ARID) family of proteins. In addition to the ARID DNA binding domain, ARID4A also contains a chromo domain and a TUDOR domain, indicating a function in chromatin organization and protein-protein interactions with methylated protein substrates. ARID4A is implicated to be involved in chromatin remodeling and epigenetic modifications and to play a role in the pathogenesis of cancer.
UniGene ID
Hs.161000
UniProt ID (eCommerce)
P29374

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.