human APOE shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human APOE.
shAAV-201199
AAV-h-APOE-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human APOE (apolipoprotein E). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AD2; APO-E; ApoE4; apolipoprotein E; apolipoprotein E3; LDLCQ5; LPG
Description (eCommerce)
Apo E contains 299 amino acid residues. It is a 34-37 kDa glycosylated protein (Rall et al., 1983). Apo E is involved with triglyceride, phospholipid, cholesteryl ester, and cholesterol transport in and out of cells and is a ligand for LDL receptors. Apo E has also been implicated in immune and nerve degeneration. It has been found to suppress lymphocyte proliferation. Late-onset familial and sporadic Alzheimer disease patients have been found to have a higher occurrence of one of the three common Apo E isoforms, Apo E4. The Apo E4 isoform has been detected in senile plaques and neurofibrillary tangles of Alzheimer disease patients. Apo E4 is associated with rapid chylomicron-remnant clearance and increased total cholesterol levels.
Description (Vector)
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Gene ID
348
Gene Name (eCommerce)
apolipoprotein E
Gene Name (Vector)
apolipoprotein E
Gene Symbol
APOE
HGNC ID
HGNC:613
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
954
ORF Size (bp)
954 bp
Protein Name (eCommerce)
Apolipoprotein E
RefSeq ID
NM_000041
RefSeq Synonyms
NM_001302691, NM_001302690, NM_001302689, NM_001302688, NM_000041, BC003557,
Research Areas
Cardiovascular
Research Areas (Faceted)
cardiovascular
Species
human
Target Sentence
Apo E contains 299 amino acid residues. It is a 34-37 kDa glycosylated protein (Rall et al., 1983). Apo E is involved with triglyceride, phospholipid, cholesteryl ester, and cholesterol transport in and out of cells and is a ligand for LDL receptors. Apo E has also been implicated in immune and nerve degeneration. It has been found to suppress lymphocyte proliferation. Late-onset familial and sporadic Alzheimer disease patients have been found to have a higher occurrence of one of the three common Apo E isoforms, Apo E4. The Apo E4 isoform has been detected in senile plaques and neurofibrillary tangles of Alzheimer disease patients. Apo E4 is associated with rapid chylomicron-remnant clearance and increased total cholesterol levels.
UniGene ID
Hs.654439
UniProt ID (eCommerce)
P02649
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.