human CORT shRNA silencing AAV

Name
AAV-h-CORT-shRNA

Cat No
shAAV-201153

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CORT.

shAAV-201153

AAV-h-CORT-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CORT (cortistatin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CST-14; CST-17; CST-29

Description (Vector)

CORT encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739.

Gene ID

1325

Gene Name (Vector)

cortistatin

Gene Symbol

CORT

HGNC ID

HGNC:2257

ORF Size (aa)

468

ORF Size (bp)

468 bp

RefSeq ID

NM_001302

RefSeq Synonyms

NM_001302, BC119725, BC119724,

Species

human

UniGene ID

Hs.412311

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.