human APEX1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human APEX1.
shAAV-201137
AAV-h-APEX1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
APE; APE1; APEN; APEX; APX; HAP1; REF1
Description (Vector)
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
Gene ID
328
Gene Name (Vector)
apurinic/apyrimidinic endodeoxyribonuclease 1
Gene Symbol
APEX1
HGNC ID
HGNC:587
ORF Size (aa)
957
ORF Size (bp)
957 bp
RefSeq ID
NM_080649
RefSeq Synonyms
NM_080649, NM_080648, NM_001641, NM_001244249, BC095428, BC019291, BC008145, BC004979, BC002338,
Species
human
UniGene ID
Hs.73722
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.