human APBB1 shRNA silencing AAV

Name
AAV-h-APBB1-shRNA

Cat No
shAAV-201120

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human APBB1.

shAAV-201120

AAV-h-APBB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human APBB1 (amyloid beta precursor protein binding family B member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FE65; MGC:9072; RIR

Description (Vector)

APBB1 is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene ID

322

Gene Name (Vector)

amyloid beta precursor protein binding family B member 1

Gene Symbol

APBB1

HGNC ID

HGNC:581

ORF Size (aa)

2127

ORF Size (bp)

2127 bp

RefSeq ID

NM_001164

RefSeq Synonyms

NM_145689, NM_001257326, NM_001257325, NM_001257323, NM_001257321, NM_001257320, NM_001257319, NM_001164, BC010854,

Species

human

UniGene ID

Hs.372840

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.