human APBA2 shRNA silencing AAV

Name 
AAV-h-APBA2-shRNA
Cat No 
shAAV-201118
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human APBA2.

shAAV-201118
AAV-h-APBA2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human APBA2 (amyloid beta precursor protein binding family A member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); amyloid-beta A4 precursor protein-binding family A member 2; D15S1518E; HsT16821; LIN-10; MGC:14091; MINT2; mint-2; neuronal munc18-1-interacting protein 2; neuron-specific X11L protein; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11-BETA; X11L; X11-like protein
Description (eCommerce)
Amyloid beta A4 precursor protein-binding family A member 2 is a member of the X11 protein family and is by the gene APBA2. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients [taken from NCBI Entrez Gene ID: 321].
Description (Vector)
APBA2 is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
321
Gene Name (eCommerce)
amyloid beta precursor protein binding family A member 2
Gene Name (Vector)
amyloid beta precursor protein binding family A member 2
Gene Symbol
APBA2
HGNC ID
HGNC:579
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2214
ORF Size (bp)
2214 bp
Protein Name (eCommerce)
Amyloid beta A4 precursor protein-binding family A member 2
RefSeq ID
NM_005503
RefSeq Synonyms
NM_005503, NM_001130414, BC082986,
Research Areas
Gene Expression,Neurobiology,Neurodevelopment
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology
Species
human
Target Sentence
Amyloid beta A4 precursor protein-binding family A member 2 is a member of the X11 protein family and is by the gene APBA2. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients [taken from NCBI Entrez Gene ID: 321].
UniGene ID
Hs.618112
UniProt ID (eCommerce)
Q99767

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.