human AOC2 shRNA silencing AAV

Name
AAV-h-AOC2-shRNA

Cat No
shAAV-201069

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human AOC2.

shAAV-201069

AAV-h-AOC2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AOC2 (amine oxidase, copper containing 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DAO2; RAO; SSAO

Description (Vector)

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.

Gene ID

314

Gene Name (Vector)

amine oxidase, copper containing 2

Gene Symbol

AOC2

HGNC ID

HGNC:549

ORF Size (aa)

2271

ORF Size (bp)

2271 bp

RefSeq ID

NM_001158

RefSeq Synonyms

NM_009590, NM_001158, BC142641,

Species

human

UniGene ID

Hs.143102

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.