human ANXA1 shRNA silencing AAV

Name 
AAV-h-ANXA1-shRNA
Cat No 
shAAV-201038
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ANXA1.

shAAV-201038
AAV-h-ANXA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ANXA1 (annexin A1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
annexin A1; Annexin I; annexin I (lipocortin I); annexin-1; ANX1; calpactin II; calpactin-2; chromobindin-9; epididymis secretory sperm binding protein; Lipocortin I; LPC1; p35; phospholipase A2 inhibitory protein
Description (eCommerce)
Annexin A1 is a membrane-localized protein that binds phospholipids. It inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression has been detected in multiple tumors [taken from NCBI Entrez Gene (Gene ID: 301)].
Description (Vector)
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
Gene ID
301
Gene Name (eCommerce)
annexin A1
Gene Name (Vector)
annexin A1
Gene Symbol
ANXA1
HGNC ID
HGNC:533
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1041
ORF Size (bp)
1041 bp
Protein Name (eCommerce)
Annexin A1
RefSeq ID
NM_000700
RefSeq Synonyms
NM_000700, BC035993, BC001275,
Research Areas
Apoptosis,Breast Cancer,Cancer,Cardiology,Cardiovascular,Cell Cycle,EGFR Signaling,GPCR Signaling,Immunology,Interleukin Signaling,Neurobiology,RNA Binding,Signal Transduction
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Annexin A1 is a membrane-localized protein that binds phospholipids. It inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression has been detected in multiple tumors [taken from NCBI Entrez Gene (Gene ID: 301)].
UniGene ID
Hs.494173
UniProt ID (eCommerce)
P04083

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.