human ANGPTL3 shRNA silencing AAV

Name
AAV-h-ANGPTL3-shRNA

Cat No
shAAV-200918

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ANGPTL3.

shAAV-200918

AAV-h-ANGPTL3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ANGPTL3 (angiopoietin like 3). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ANG-5; ANGPT5; ANL3; FHBL2

Description (Vector)

ANGPTL3 is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.

Gene ID

27329

Gene Name (Vector)

angiopoietin like 3

Gene Symbol

ANGPTL3

HGNC ID

HGNC:491

ORF Size (aa)

1383

ORF Size (bp)

1383 bp

RefSeq ID

NM_014495

RefSeq Synonyms

NM_014495, BC058287,

Species

human

UniGene ID

Hs.209153

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.