human ALAD shRNA silencing AAV

Name
AAV-h-ALAD-shRNA

Cat No
shAAV-200712

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ALAD.

shAAV-200712

AAV-h-ALAD-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ALAD (aminolevulinate dehydratase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ALADH; PBGS

Description (Vector)

The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.

Gene ID

210

Gene Name (Vector)

aminolevulinate dehydratase

Gene Symbol

ALAD

HGNC ID

HGNC:395

ORF Size (aa)

1020

RefSeq ID

NM_000031

RefSeq Synonyms

NM_001317745, NM_001003945, NM_000031, BC000977,

Species

human

UniGene ID

Hs.1227

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.