human AKR1C4 shRNA silencing AAV

Name 
AAV-h-AKR1C4-shRNA
Cat No 
shAAV-200688
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human AKR1C4.

shAAV-200688
AAV-h-AKR1C4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AKR1C4 (aldo-keto reductase family 1 member C4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
3-alpha-HSD; C11; CDR; CHDR; DD-4; DD4; HAKRA
Description (Vector)
AKR1C4 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Gene ID
1109
Gene Name (Vector)
aldo-keto reductase family 1 member C4
Gene Symbol
AKR1C4
HGNC ID
HGNC:387
ORF Size (aa)
972
ORF Size (bp)
972 bp
RefSeq ID
NM_001818
RefSeq Synonyms
NM_001818, BC020744,
Species
human
UniGene ID
Hs.567245

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.