human AKAP1 shRNA silencing AAV

Name 
AAV-h-AKAP1-shRNA
Cat No 
shAAV-200649
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human AKAP1.

shAAV-200649
AAV-h-AKAP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AKAP1 (A-kinase anchoring protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
A kinase (PRKA) anchor protein 1; AKAP; AKAP 149; AKAP121; AKAP149; AKAP84; A-kinase anchor protein 1, mitochondrial; A-kinase anchor protein 149 kDa; D-AKAP1; D-AKAP-1; Dual specificity A-kinase-anchoring protein 1; dual-specificity A-kinase anchoring protein 1; PPP1R43; PRKA1; protein kinase A anchoring protein 1; protein kinase A1; Protein kinase A-anchoring protein 1; protein phosphatase 1, regulatory subunit 43; SAKAP84; S-AKAP84; spermatid A-kinase anchor protein 84; TDRD17; testicular secretory protein Li 5; tudor domain containing 17
Description (eCommerce)
AKAP1 (A-kinase anchor protein 1) was isolated as a protein that interacts with the regulatory subunit of protein kinase A (PKA) as well as the catalytic subunit of protein phosphatase 1 (PPI). AKAP1 plays a role in directing the subcellular localization of PKA to the cytoplasmic face of the outer mitochondrial membrane.
Description (Vector)
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.
Gene ID
8165
Gene Name (eCommerce)
A-kinase anchoring protein 1
Gene Name (Vector)
A-kinase anchoring protein 1
Gene Symbol
AKAP1
HGNC ID
HGNC:367
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2712
ORF Size (bp)
2712 bp
Protein Name (eCommerce)
A-kinase anchor protein 1, mitochondrial
RefSeq ID
NM_003488
RefSeq Synonyms
NM_003488, NM_001242903, NM_001242902, BC000729,
Research Areas
Cardiac Hypertrophy,Cardiology,Cardiovascular,Kinase/Phosphatase,Mitochondrion,Neurobiology,RNA Binding,RNA Processing,Signal Transduction,VEGF Signaling
Research Areas (Faceted)
cardiovascular,cell_biology,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
AKAP1 (A-kinase anchor protein 1) was isolated as a protein that interacts with the regulatory subunit of protein kinase A (PKA) as well as the catalytic subunit of protein phosphatase 1 (PPI). AKAP1 plays a role in directing the subcellular localization of PKA to the cytoplasmic face of the outer mitochondrial membrane.
UniGene ID
Hs.463506
UniProt ID (eCommerce)
Q92667

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.