human AGXT shRNA silencing AAV

Name
AAV-h-AGXT-shRNA

Cat No
shAAV-200585

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human AGXT.

shAAV-200585

AAV-h-AGXT-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AGXT (alanine-glyoxylate aminotransferase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AGT; AGT1; AGXT1; PH1; SPAT; SPT; TLH6

Description (Vector)

AGXT is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria.

Gene ID

189

Gene Name (Vector)

alanine-glyoxylate aminotransferase

Gene Symbol

AGXT

HGNC ID

HGNC:341

ORF Size (aa)

1179

ORF Size (bp)

1179 bp

RefSeq ID

NM_000030

RefSeq Synonyms

NM_000030, BC132819,

Species

human

UniGene ID

Hs.144567

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.