human AGPS shRNA silencing AAV

Name
AAV-h-AGPS-shRNA

Cat No
shAAV-200577

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human AGPS.

shAAV-200577

AAV-h-AGPS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AGPS (alkylglycerone phosphate synthase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADAP-S; ADAS; ADHAPS; ADPS; ALDHPSY; RCDP3

Description (Vector)

AGPS is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome.

Gene ID

8540

Gene Name (Vector)

alkylglycerone phosphate synthase

Gene Symbol

AGPS

HGNC ID

HGNC:327

ORF Size (aa)

1977

ORF Size (bp)

1977 bp

RefSeq ID

NM_003659

RefSeq Synonyms

NM_003659, BC141820,

Species

human

UniGene ID

Hs.516543

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.