human ADRA2C shRNA silencing AAV

Name
AAV-h-ADRA2C-shRNA

Cat No
shAAV-200505

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ADRA2C.

shAAV-200505

AAV-h-ADRA2C-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADRA2C (adrenoceptor alpha 2C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR

Description (Vector)

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

Gene ID

152

Gene Name (Vector)

adrenoceptor alpha 2C

Gene Symbol

ADRA2C

HGNC ID

HGNC:283

ORF Size (aa)

1389

ORF Size (bp)

1389 bp

RefSeq ID

NM_000683

RefSeq Synonyms

NM_000683, BC142625,

Species

human

UniGene ID

Hs.123022

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.