human ADRA1B shRNA silencing AAV

Name
AAV-h-ADRA1B-shRNA

Cat No
shAAV-200499

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ADRA1B.

shAAV-200499

AAV-h-ADRA1B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADRA1B (adrenoceptor alpha 1B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADRA1; ALPHA1BAR

Description (Vector)

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

Gene ID

147

Gene Name (Vector)

adrenoceptor alpha 1B

Gene Symbol

ADRA1B

HGNC ID

HGNC:278

ORF Size (aa)

1563

ORF Size (bp)

1563 bp

RefSeq ID

NM_000679

RefSeq Synonyms

NM_000679, BC136569, BC136568,

Species

human

UniGene ID

Hs.368632

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.