human ADCY4 shRNA silencing AAV

Name
AAV-h-ADCY4-shRNA

Cat No
shAAV-200426

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ADCY4.

shAAV-200426

AAV-h-ADCY4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADCY4 (adenylate cyclase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AC4

Description (Vector)

ADCY4 encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants.

Gene ID

196883

Gene Name (Vector)

adenylate cyclase 4

Gene Symbol

ADCY4

HGNC ID

HGNC:235

ORF Size (aa)

3234

ORF Size (bp)

3234 bp

RefSeq ID

NM_139247

RefSeq Synonyms

NM_139247, NM_001198592, NM_001198568, BC117475, BC117473,

Species

human

UniGene ID

Hs.443428

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.