human ADAR shRNA silencing AAV

Name 
AAV-h-ADAR-shRNA
Cat No 
shAAV-200406
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ADAR.

shAAV-200406
AAV-h-ADAR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADAR (adenosine deaminase, RNA specific). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
136 kDa double-stranded RNA-binding protein; ADAR1; adenosine deaminase acting on RNA 1-A; AGS6; double-stranded RNA-specific adenosine deaminase; DRADA; DSH; DSRAD; dsRNA adenosine deaminase; dsRNA adeonosine deaminase; G1P1; IFI4; IFI-4; interferon-induced protein 4; interferon-inducible protein 4; K88DSRBP; P136
Description (eCommerce)
ADAR1 (adenosine deaminase, RNA specific) is an enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditary [taken from NCBI Entrez Gene (Gene ID: 103)].
Description (Vector)
ADAR encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.
Gene ID
103
Gene Name (eCommerce)
adenosine deaminase, RNA specific
Gene Name (Vector)
adenosine deaminase, RNA specific
Gene Symbol
ADAR
HGNC ID
HGNC:225
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3681
ORF Size (bp)
3681 bp
Protein Name (eCommerce)
Double-stranded RNA-specific adenosine deaminase
RefSeq ID
NM_001111
RefSeq Synonyms
NM_015841, NM_015840, NM_001193495, NM_001111, NM_001025107, BC038227,
Research Areas
Apoptosis,Gene Expression,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,mRNA Processing,Response to Virus,RNA Binding,RNA Processing,Signal Transduction,Spliceosome
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
ADAR1 (adenosine deaminase, RNA specific) is an enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditary [taken from NCBI Entrez Gene (Gene ID: 103)].
UniGene ID
Hs.12341
UniProt ID (eCommerce)
P55265

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.