human ADAMTS14 shRNA silencing AAV

Name
AAV-h-ADAMTS14-shRNA

Cat No
shAAV-200380

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ADAMTS14.

shAAV-200380

AAV-h-ADAMTS14-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADAMTS14 (ADAM metallopeptidase with thrombospondin type 1 motif 14). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

ADAMTS14 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. ADAMTS14 is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined.

Gene ID

140766

Gene Name (Vector)

ADAM metallopeptidase with thrombospondin type 1 motif 14

Gene Symbol

ADAMTS14

HGNC ID

HGNC:14899

ORF Size (aa)

3678

ORF Size (bp)

3678 bp

RefSeq ID

NM_080722

RefSeq Synonyms

NM_139155, NM_080722, BC140263,

Species

human

UniGene ID

Hs.352156

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.