human ACVR2B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ACVR2B.
shAAV-200331
AAV-h-ACVR2B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ACVR2B (activin A receptor, type IIB). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ActR-IIB; ACTRIIB; MGC116908;
Description (Vector)
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
Gene ID
93
Gene Name (Vector)
activin A receptor, type IIB
Gene Symbol
ACVR2B
ORF Size (aa)
912
ORF Size (bp)
912 bp
RefSeq ID
NM_001106
RefSeq Synonyms
NM_001106, BC099642, BC096245, BC096244, BC096243,
Species
human
UniGene ID
Hs.174273
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.