human ACVR1C shRNA silencing AAV

Name 
AAV-h-ACVR1C-shRNA
Cat No 
shAAV-200325
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ACVR1C.

shAAV-200325
AAV-h-ACVR1C-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACVR1C (activin A receptor type 1C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ACVRLK7; ALK7
Description (Vector)
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 (PubMed 12063393)).(supplied by OMIM, Mar 2008)
Gene ID
130399
Gene Name (Vector)
activin A receptor type 1C
Gene Symbol
ACVR1C
HGNC ID
HGNC:18123
ORF Size (aa)
1482
ORF Size (bp)
1482 bp
RefSeq ID
NM_145259
RefSeq Synonyms
NM_145259, NM_001111033, NM_001111032, NM_001111031, BC022530,
Species
human
UniGene ID
Hs.562901

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.