human ACVR1B shRNA silencing AAV

Name
AAV-h-ACVR1B-shRNA

Cat No
shAAV-200323

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ACVR1B.

shAAV-200323

AAV-h-ACVR1B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACVR1B (activin A receptor type 1B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACTRIB; ACVRLK4; ALK4; SKR2

Description (Vector)

ACVR1B encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.

Gene ID

Gene Name (Vector)

activin A receptor type 1B

Gene Symbol

ACVR1B

HGNC ID

HGNC:172

ORF Size (aa)

1518

ORF Size (bp)

1518 bp

RefSeq ID

NM_004302

RefSeq Synonyms

NM_020328, NM_020327, NM_004302, BC040531, BC000254,

Species

human

UniGene ID

Hs.438918

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.