human ACTN3 shRNA silencing AAV

Name
AAV-h-ACTN3-shRNA

Cat No
shAAV-200303

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ACTN3.

shAAV-200303

AAV-h-ACTN3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACTN3 (actinin alpha 3 (gene/pseudogene)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

ACTN3 encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants. The reference genome contains the non-coding allele. The non-functional allele of this gene is associated with elite athlete status.

Gene ID

Gene Name (Vector)

actinin alpha 3 (gene/pseudogene)

Gene Symbol

ACTN3

HGNC ID

HGNC:165

ORF Size (aa)

2706

ORF Size (bp)

2706 bp

RefSeq ID

NM_001104

RefSeq Synonyms

NM_001258371, NM_001104, BC099649, BC099647,

Species

human

UniGene ID

Hs.654432

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.