human ACO1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ACO1.
shAAV-200198
AAV-h-ACO1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ACO1 (aconitase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1
Description (Vector)
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Gene ID
48
Gene Name (Vector)
aconitase 1
Gene Symbol
ACO1
HGNC ID
HGNC:117
ORF Size (aa)
2670
ORF Size (bp)
2670 bp
RefSeq ID
NM_002197
RefSeq Synonyms
NM_002197, NM_001278352, BC018103,
Species
human
UniGene ID
Hs.567229
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.