human ACMSD shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ACMSD.
shAAV-200194
AAV-h-ACMSD-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ACMSD (aminocarboxymuconate semialdehyde decarboxylase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.(supplied by OMIM, Oct 2004)
Gene ID
130013
Gene Name (Vector)
aminocarboxymuconate semialdehyde decarboxylase
Gene Symbol
ACMSD
HGNC ID
HGNC:19288
ORF Size (aa)
1011
RefSeq ID
NM_138326
RefSeq Synonyms
NM_138326, NM_001307983, BC107420, BC016018,
Species
human
UniGene ID
Hs.655728
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.