human ABL1 shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-200127
Availability:
4-5 weeks
Name:
AAV-h-ABL1-shRNA
This is an AAV expressing shRNA for silencing of Human ABL1.
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Product Info
- Knockdown
- >90% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- ABL1
- Gene Name
- ABL proto-oncogene 1, non-receptor tyrosine kinase
- Gene ID
- 25
- Gene Synonyms
- ABL; bcr/abl; c-ABL; c-ABL1; JTK7; p150; v-abl
- ORF Size
- 3450 bp
- RefSeq#
- NM_007313
- Gene Description
- The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
- UniGene ID
- Hs.431048
- HGNC ID
- HGNC:76
Related Products
Product | Cat No. |
---|---|
AAV-h-ABL1 | AAV-200127 |
AAV-m-ABL1 | AAV-251833 |
Ad-h-ABL1 | ADV-200127 |
Ad-m-ABL1 | ADV-251833 |
AAV-m-ABL1-shRNA | shAAV-251833 |
Ad-h-ABL1-shRNA | shADV-200127 |
Ad-m-ABL1-shRNA | shADV-251833 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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