human ABCG5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ABCG5.
shAAV-200101
AAV-h-ABCG5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ABCG5 (ATP binding cassette subfamily G member 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
STSL
Description (Vector)
ABCG5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. ABCG5 functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.
Gene ID
64240
Gene Name (Vector)
ATP binding cassette subfamily G member 5
Gene Symbol
ABCG5
HGNC ID
HGNC:13886
ORF Size (aa)
1953
ORF Size (bp)
1953 bp
RefSeq ID
NM_022436
RefSeq Synonyms
NM_022436, BC172287,
Species
human
UniGene ID
Hs.132992
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.