human AADAT shRNA silencing AAV

Cat. No: shAAV-200019

Availability: 6-8 weeks

Name: AAV-h-AADAT-shRNA

This is an AAV expressing shRNA for silencing of Human AADAT.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: AADAT
Gene Name: aminoadipate aminotransferase
Gene ID: 51166
Gene Synonyms: KAT2; KATII; KYAT2
ORF Size: 1290 bp
RefSeq#: NM_016228
Gene Description: AADAT encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist.
UniGene ID: Hs.529735
HGNC ID: HGNC:17929