rat SIRPA Adenovirus
This is an Adenovirus expressing Rat Sirpa.
ADV-294438
Ad-r-SIRPA
Ready-to-use Adenovirus expressing Rat Sirpa (signal-regulatory protein alpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Bit; Ptpns1; SHPS-1
Description (Vector)
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Gene ID
25528
Gene Name (Vector)
signal-regulatory protein alpha
Gene Symbol
Sirpa
ORF Size (aa)
1542
ORF Size (bp)
1542 bp
RefSeq ID
NM_013016
RefSeq Synonyms
NM_013016, BC099773,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.