rat BBS7 Adenovirus

Name
Ad-r-BBS7

Cat No
ADV-290770

Availability
4-5 weeks

This is an Adenovirus expressing Rat Bbs7.

ADV-290770

Ad-r-BBS7

Ready-to-use Adenovirus expressing Rat Bbs7 (Bardet-Biedl syndrome 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Description (Vector)

The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.

Gene ID

361930

Gene Name (Vector)

Bardet-Biedl syndrome 7

Gene Symbol

Bbs7

ORF Size (aa)

2148

ORF Size (bp)

2148 bp

RefSeq ID

NM_001012180

RefSeq Synonyms

NM_001012180, BC081968,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.