mouse DKK1 Adenovirus

Name 
Ad-m-DKK1
Cat No 
ADV-280686
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Mouse Dkk1.

ADV-280686
Ad-m-DKK1

Ready-to-use Adenovirus expressing Mouse Dkk1 (dickkopf WNT signaling pathway inhibitor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
mdkk-1
Description (Vector)
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Gene ID
13380
Gene Name (Vector)
dickkopf WNT signaling pathway inhibitor 1
Gene Symbol
Dkk1
ORF Size (aa)
819
ORF Size (bp)
819 bp
RefSeq ID
NM_010051
RefSeq Synonyms
NM_010051, BC050189,
Species
mouse
UniGene ID
Mm.214717

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.