mouse ZCCHC11 Adenovirus
This is an Adenovirus expressing Mouse Coa6.
ADV-276575
Ad-m-ZCCHC11
Ready-to-use Adenovirus expressing Mouse Zcchc11 (zinc finger, CCHC domain containing 11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
6030404K05Rik; 9230115F04Rik; mKIAA0191; PPAPD3
Description (Vector)
Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.
Gene ID
230594
Gene Name (Vector)
zinc finger, CCHC domain containing 11
Gene Symbol
Zcchc11
ORF Size (aa)
4935
ORF Size (bp)
4935 bp
RefSeq ID
NM_175472
RefSeq Synonyms
NM_175472, BC150791,
Species
mouse
UniGene ID
Mm.446602
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.