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mouse SHARPIN Adenovirus

Name 
Ad-m-SHARPIN
Cat No 
ADV-271932
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Mouse Sharpin.

ADV-271932
Ad-m-SHARPIN

Ready-to-use Adenovirus expressing Mouse Sharpin (SHANK-associated RH domain interacting protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
0610041B22Rik; AW121341; cpdm; RBCKL1; SIPL1
Description (Vector)
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex.
Gene ID
106025
Gene Name (Vector)
SHANK-associated RH domain interacting protein
Gene Symbol
Sharpin
ORF Size (aa)
918
ORF Size (bp)
918 bp
RefSeq ID
NM_025340
RefSeq Synonyms
NM_025340, BC055758, BC016203,
Species
mouse
UniGene ID
Mm.41463

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.