mouse SET Adenovirus
This is an Adenovirus expressing Mouse Set.
ADV-271753
Ad-m-SET
Ready-to-use Adenovirus expressing Mouse Set (SET nuclear oncogene). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610030F17Rik; 5730420M11Rik; AA407739; I-2PP2A; StF-IT-1; TAF-I
Description (Vector)
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.
Gene ID
56086
Gene Name (Vector)
SET nuclear oncogene
Gene Symbol
Set
ORF Size (aa)
870
ORF Size (bp)
870 bp
RefSeq ID
NM_023871
RefSeq Synonyms
NM_023871, NM_001204875, BC103791, BC018255,
Species
mouse
UniGene ID
Mm.335942
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.