mouse PLEKHO1 Adenovirus
This is an Adenovirus expressing Mouse Plekho1.
ADV-268874
Ad-m-PLEKHO1
Ready-to-use Adenovirus expressing Mouse Plekho1 (pleckstrin homology domain containing, family O member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2
Description (Vector)
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Gene ID
67220
Gene Name (Vector)
pleckstrin homology domain containing, family O member 1
Gene Symbol
Plekho1
ORF Size (aa)
1227
ORF Size (bp)
1227 bp
RefSeq ID
NM_023320
RefSeq Synonyms
NM_023320, BC125441, BC117003,
Species
mouse
UniGene ID
Mm.458147
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.