mouse PIAS4 Adenovirus

Name
Ad-m-PIAS4

Cat No
ADV-268600

Availability
4-5 weeks

This is an Adenovirus expressing Mouse Pias4.

ADV-268600

Ad-m-PIAS4

Ready-to-use Adenovirus expressing Mouse Pias4 (protein inhibitor of activated STAT 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Pias-gamma; Piasg; PIASY

Description (Vector)

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.

Gene ID

59004

Gene Name (Vector)

protein inhibitor of activated STAT 4

Gene Symbol

Pias4

ORF Size (aa)

1524

ORF Size (bp)

1524 bp

RefSeq ID

NM_021501

RefSeq Synonyms

NM_021501, BC025159,

Species

mouse

UniGene ID

Mm.34428

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.