mouse PCSK1N Adenovirus

Name 
Ad-m-PCSK1N
Cat No 
ADV-268241
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Mouse Pcsk1n.

ADV-268241
Ad-m-PCSK1N

Ready-to-use Adenovirus expressing Mouse Pcsk1n (proprotein convertase subtilisin/kexin type 1 inhibitor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AI848336; bLEN; KEP; lLEN; Pan3; PEN; PEN19; PEN20; proSAAS; SAAS; SAASCT
Description (Vector)
PCSK1N may function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity).
Gene ID
30052
Gene Name (Vector)
proprotein convertase subtilisin/kexin type 1 inhibitor
Gene Symbol
Pcsk1n
ORF Size (aa)
777
RefSeq ID
NM_013892
RefSeq Synonyms
NM_013892, BC012263,
Species
mouse
UniGene ID
Mm.4881

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.