mouse PAK1 Adenovirus
This is an Adenovirus expressing Mouse Pak1.
ADV-268015
Ad-m-PAK1
Ready-to-use Adenovirus expressing Mouse Pak1 (p21 protein (Cdc42/Rac)-activated kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW045634; PAK-1; Paka
Description (Vector)
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2.
Gene ID
18479
Gene Name (Vector)
p21 protein (Cdc42/Rac)-activated kinase 1
Gene Symbol
Pak1
ORF Size (aa)
1635
ORF Size (bp)
1635 bp
RefSeq ID
NM_011035
RefSeq Synonyms
NM_011035, BC167167,
Species
mouse
UniGene ID
Mm.260227
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.