mouse NDP Adenovirus
This is an Adenovirus expressing Mouse Ndp.
ADV-265545
Ad-m-NDP
Ready-to-use Adenovirus expressing Mouse Ndp (Norrie disease (pseudoglioma) (human)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ND; Ndph
Description (Vector)
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Gene ID
17986
Gene Name (Vector)
Norrie disease (pseudoglioma) (human)
Gene Symbol
Ndp
ORF Size (aa)
396
ORF Size (bp)
396 bp
RefSeq ID
NM_010883
RefSeq Synonyms
NM_010883, BC090623,
Species
mouse
UniGene ID
Mm.5014
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.