mouse MST1R Adenovirus
This is an Adenovirus expressing Mouse Mst1r.
ADV-265071
Ad-m-MST1R
Ready-to-use Adenovirus expressing Mouse Mst1r (macrophage stimulating 1 receptor (c-met-related tyrosine kinase)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD136; CDw136; Fv-2; Fv2; PTK8; Ron; STK
Description (Vector)
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
Gene ID
19882
Gene Name (Vector)
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Gene Symbol
Mst1r
ORF Size (aa)
4137
ORF Size (bp)
4137 bp
RefSeq ID
NM_009074
RefSeq Synonyms
NM_009074, NM_001287261, BC141379,
Species
mouse
UniGene ID
Mm.3901
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.