mouse MARK1 Adenovirus

Name
Ad-m-MARK1

Cat No
ADV-264270

Availability
4-5 weeks

This is an Adenovirus expressing Mouse Mark1.

ADV-264270

Ad-m-MARK1

Ready-to-use Adenovirus expressing Mouse Mark1 (MAP/microtubule affinity regulating kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

AW491150; B930025N23Rik; Emk3; mKIAA1477; mPar-1c; Par-1c

Description (Vector)

Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Gene ID

226778

Gene Name (Vector)

MAP/microtubule affinity regulating kinase 1

Gene Symbol

Mark1

ORF Size (aa)

2388

ORF Size (bp)

2388 bp

RefSeq ID

NM_145515

RefSeq Synonyms

NM_145515, BC112400,

Species

mouse

UniGene ID

Mm.7445

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.