mouse KCTD11 Adenovirus
This is an Adenovirus expressing Mouse Kctd11.
ADV-262724
Ad-m-KCTD11
Ready-to-use Adenovirus expressing Mouse Kctd11 (potassium channel tetramerisation domain containing 11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AF465352; Ren
Description (Vector)
Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
Gene ID
216858
Gene Name (Vector)
potassium channel tetramerisation domain containing 11
Gene Symbol
Kctd11
ORF Size (aa)
699
RefSeq ID
NM_153143
RefSeq Synonyms
NM_153143, BC052734, BC052502,
Species
mouse
UniGene ID
Mm.239498
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.